Here’s another question and answer from my February interview with Dr. Cynthia Shelby-Lane regarding the need for coenzyme Q10 to prevent heart disease.
Lisa Nelson, RD: How much coenzyme Q10, if any, should individuals with heart disease supplement to see benefits?
Dr. Shelby-Lane: CoenzymeQ10-H2, also known as ubiquinol, is the reduced form of coenzymeQ10 (CoQ10) that is over five times more bioavailable than ordinary (standard) CoQ10. CoQ10 plays a vital role in the mitochondria, which are responsible for over 90% of the body’s energy production. Mitochondria can truly be described as the cell’s “blast furnaces,” and CoQ10 plays a critical role in the utilization of oxygen inside these mitochondria. CoQ10 also acts as an antioxidant to protect the mitochondria against the massive free radical production that occurs during the cell’s energy-producing respiratory cycle.
What is ubiquinol?
The active, already-reduced form of coenzyme Q10 that the body can use directly, without converting it first. It’s more readily absorbed than standard CoQ10.
CoQ10 is produced naturally in all cells, but there is an age-related decline in CoQ10 production that has been linked to a wide variety of disorders in humans. Heart cells were the first cells discovered that suffered major declines in CoQ10 with age, but we now know that CoQ10 levels decline with age in almost all cells. It is vital for our health to supply dietary CoQ10 to offset the inevitable age-related decline in CoQ10 levels that occurs throughout the human body.
Continue readingA few days ago, I shared a little information on the nutrient L-carnitine. I want to give you a few more details related to this nutrient.
Let’s review the function of L-carnitine. In order for the heart to pump blood it needs fuel. This fuel is produced in the mitochondria of your cells. The hearts preferred energy source is fatty acids. Coenzyme Q10 is needed for the production of ATP (fuel) within the mitochondria. L-carnitine is needed for the transport of fatty acids to the mitochondria. Most people with heart disease are deficient of coenzyme Q10 and benefit from supplementation. Some individuals with heart disease are also deficient in L-carnitine and will only see improvements if Coenzyme Q10 and L-carnitine are supplemented together.
Even though your body can produce L-carnitine deficiencies do occur. A deficiency can be caused by aging, vegetarian diets, diet deficient in iron, diets low in the vitamins B6, niacin, and vitamin C, liver disease, kidney disease, and certain medications (such as anti-convulsant drugs). As I mentioned above, a damaged heart also promotes an L-carnitine deficiency.
Combined supplementation of L-Carnitine and coenzyme Q10 have improved many cardiovascular situations:
1. Angina
2. Congestive Heart Failure
3. Renal insufficiency
4. Arrhythmia
5. Hyperlipidemia (high cholesterol, high LDL cholesterol, high triglycerides)
6. Leg Cramps
Some sources of L-carnitine include mutton, lamb, beef (red meat), and pork.
There are two forms of L-carnitine available at health food stores – fumarate and tartrate. So far, L-carnitine tartrate has been found to be more efficient for individuals with heart disease. New forms of L-carnitine are being researched and may become available, also.
While there are no known side effects from supplementing L-carnitine, always consult your physician regarding any and all supplements you currently take and/or would like to supplement.
All the best,
Lisa Nelson RD
Be Heart Healthy and Lose Weight
This is probably a supplement you’ve never heard of, but when supplemented along with coenzyme Q10 substantial benefits have been seen in individuals with heart disease.
L-carnitine is a compound produced by the liver and kidneys from the biosynthesis of the amino acids lysine and methionine. To form L-carnitine you also need adequate levels of vitamin C, B6, niacin, and iron.
Let me explain how L-carnitine works. The powerhouse of your cells is the mitochondria and produces the energy your heart needs to function. L-carnitine is responsible for transporting fatty acids to the mitochondria for energy production. The heart typically gets 60% of its energy from fat sources. If this process is slowed due to a lack of L-carnitine heart function is affected, especially compounding problems for individuals with heart disease. Those with moderate to severe atherosclerosis (hardening of the arteries due to inflammation and cholesterol deposits) and congestive heart failure are most affected by a deficiency of L-carnitine. Too make matters worse, damaged heart tissue has a hard time “holding on” to L-carnitine resulting in a deficiency.
If you remember back to the information I shared on Coenzyme Q10, Coenzyme Q10 directly affects energy production in the mitochondria. When Coenzyme Q10 levels are low, cells are unable to produce energy, meaning the heart lacks the fuel it needs to pump blood.
About 85% of individuals with heart disease respond positively to coenzyme Q10 supplementation and significant improvements to their heart health. However, ~10-15% do not see any improvements from the addition of coenzyme Q10. Researchers have learned the “missing link” for these individuals is L-carnitine. The combination of L-carnitine with Coenzyme Q10 is needed for some individuals to experience the additional energy boost and improved heart function.
Signs of improvements many individuals see from a combination of L-carnitine and Coenzyme Q10 include better color, easier breathing, and less difficulty with exertion activities.
All the best,
Lisa Nelson RD
Heart Healthy Tips
Research suggests CoQ10 supplementation may offer several benefits:
Consult your doctor to determine if supplementing CoQ10 is the right treatment option for your situation.
Tired of changes that don't last?
All the best,
Lisa Nelson, RD
Symptoms associated with a CoQ10 deficiency develop gradually over time, so it’s very easy to miss the signs.
Symptoms include: aches and pains, fatigue, sore muscles, weakness, malaise, and shortness of breath
Our bodies are designed for CoQ10 to be formed from a variety of vitamins, minerals, and amino acids. If your intake of vitamin C, B-12, B-6, pantothenic acid, and various other minerals and nutrients is deficient, the production of CoQ10 is compromised. Conditions and medications, such as hyperthyroidism, antidepressants, gum disease, and advanced age will also cause lower than adequate levels of CoQ10.
All the best,
Lisa Nelson RD
The powerhouse of your cells is the mitochondria. The mitochondria convert the foods you eat into energy your body can use. The form of energy the body uses is called ATP. ATP is produced within the mitochondria by taking needed electrons from foods. CoQ10 is responsible for carrying the electrons back and forth between enzymes in the production of ATP.
If that was a little too much science for you, let me make it much simpler.
Without CoQ10 your cells can not produce energy for your body to function, including the heart muscle. The heart uses an enormous amount of energy to function and maintain blood circulation 24/7.
CoQ10 is especially beneficial if you have narrowed arteries and reduced blood flow to the heart. CoQ10 uses what little oxygen and nutrients the heart receives to increase the production of ATP and boost the heart’s energy levels.
Physicians routinely using CoQ10 as part of their treatment plan for heart patients often refer to CoQ10 as “the miracle supplement” due to the drastic improvements to patient heart function.
All the best,
Lisa Nelson RD