niacin

The Best Type of Rice to Promote Heart Health

Rice is frequently consumed in combination with other foods, such as vegetables, beans, and meat. It is a low cost food, so it allows you to stretch your food budget.

There are many varieties of rice, many of which you are probably not familiar with, such as Arborio, black, red, jasmine, basmati, and then the more common wild, brown, and white.

All rice provides a variety of nutrients, including carbohydrates and protein. Plus, rice is gluten free. A one cup serving of wild rice even contains 156 mg of omega 3 fatty acids to help promote heart health and lower cholesterol.

The two most common include white rice and brown rice, so let’s by compare these two options.

White Rice vs. Brown Rice
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Niacin–Statin Study Didn't Give Desired Results: Stopped Early

The National Institutes of Health stopped a clinical trial studying a blood lipid treatment 18 months early. The study found that adding high dose, extended release niacin to statin treatment for patients with heart disease did not reduce cardiovascular events, such as heart attacks and strokes.

Study Participants

This study was referred to as AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health) and the 3414 participants were selected because they were at risk for cardiovascular events despite having a well controlled LDL cholesterol level. They were at increased risk due to a history of heart disease combined with low HDL cholesterol and high triglycerides. Low HDL levels and high triglycerides are both linked to increased risk of cardiovascular events.

Study participants were divided into two groups.

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Increase HDL Cholesterol – How Much Niacin?

A subscriber to The Heart of Health submitted the following question.

“Hello Lisa – Just read the article concerning subject matter (Zetia versus Niacin) and would appreciate knowing if there are Niacin brands and/or amount of dosage you can recommend. As information, I have taken 50 Mg of Niacin for approximately 2 years along with Vytorin, and my Cardiologist is very happy with my blood results and other testing. Thank you very much.”

Recommended dosage for niacin varies drastically from 50-3,000 mg per day. So, you are on the right track working with your physician to determine what level is best for you. In the study you reference above, the niacin level prescribed was 2000 mg per day. Dr. Stephan Sinatra reports in his book Reverse Heart Disease Now that he typically finds 1500-2000 mg enough for more people to raise low HDL levels.

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Lower Cholesterol Effectively – Zetia Versus Niacin

It often feels like pharmaceutical companies often get wrapped up in dollar signs and forget the bottom-line reason for manufacturing the medication – improving your health. A study compared the effectiveness of Niacin versus Zetia.

The study

The study was published in the New England Journal of Medicine this past November 2009. Researchers analyzed the effect of extended-release niacin and ezetimibe (Zetia) on LDL cholesterol and HDL cholesterol levels.

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Lower Cholesterol – Do you need to treat a low HDL level?

Here’s another question I asked Dr. Cynthia Shelby-Lane and her answer.

Lisa Nelson RD: Should individuals with low HDL levels receive treatment even if all other levels are normal?

Dr. Shelby-Lane: According to ScienceDaily (May 29, 2005) — High circulating levels of the “good cholesterol” HDL are associated with decreased risk of cardiovascular disease. HDL helps the liver excrete extra cholesterol by binding to a receptor in the liver called scavenger receptor-BI (SR-BI). However, the signaling events between HDL and SR-BI that afforded heart healthy benefits were not known.

In a study appearing online on March 24, 2005, in advance of the April 1, 2005 print edition of the Journal of Clinical Investigation, Philip Shaul and colleagues from the University of Texas Southwestern Medical Center examine the following pathway:

The authors show that HDL activates an enzyme called eNOS and sets off a cellular signal that depends on cholesterol efflux and two intact domains of SR-BI — the transmembrane domain and its cytoplasmic tail. These regions of SR-BI may serve as “cholesterol sensors” which set into motion cellular events to activate eNOS. This may be the mechanism responsible for the ability of HDL to reduce cardiovascular disease risk.

Lisa Nelson RD: Again, let’s clarify. If an individual has low HDL levels they should seek treatment even if all other cholesterol levels are normal. Correct? Correct?

Dr. Shelby-Lane: Again, a low HDL is an isolated risk factor and should be included in the overall health picture, and can be modified with diet, nutrition, and some newer drugs.

February is American Heart Month. In recognition of American Heart Month you can access Heart Health Made Easy at a 25% savings. Learn more about this take action guide to lower cholesterol and blood pressure at http://www.hearthealthmadeeasy.com.

All the best,
Lisa Nelson RD
How to Lower Cholesterol in 8 Simple Steps

Lower Cholesterol – Is grapefruit juice safe with medications, such as Lipitor?

grapefruit juice and medicationHere’s another question I asked Dr. Cynthia Shelby-Lane and her answer.

Lisa Nelson RD: Is it safe for individuals taking medication for heart disease, such as Lipitor, to eat grapefruit or drink grapefruit juice?

Dr. Shelby-Lane: I am including information that may help answer your question about grapefruit and a variety of nutritionals that affect statin drugs for the lowering of cholesterol.

Zocor (Simvastatin), for example, is a Statin drug, used to lower high cholesterol levels, and also known as HMG-CoA reductase inhibitor. Zocor may affect the absorption or utilization of vitamins E and coenzyme Q10. Tests showed the average concentration of coenzyme Q10 in blood plasma decreased by approximately 50% after statins were used for 30 days. Supplementation is considered beneficial.

Grapefruit and grapefruit juice may increase the effects of HMG-CoA reductase inhibitors and should not be consumed at the same time. It is suggested that these medications be taken with water. Grapefruit contains substances that may inhibit the body’s ability to break down statin drugs increasing the toxicity of the drug. Muscle pain, tenderness, or muscle weakness may be a result. If you begin to notice these symptoms, contact your doctor.

Niacin is the form of vitamin B3 used to lower cholesterol. Large amounts of niacin taken with a statin drug may cause serious muscle disorders (myopathy). Reasonable levels of niacin combined with statin drugs have been shown to enhance the cholesterol lowering effect. For proper dosage, consult your physician before taking niacin.

Pomegranate juice has been shown to inhibit the same enzyme inhibited by grapefruit juice. This may cause reactions similar to grapefruit juice when it is used with statin drug treatments.

A study of 37 people with high cholesterol treated with diet and statin drugs found vitamin A increased in the blood over two years of therapy. People taking statin drugs and vitamin A supplements should have blood levels of vitamin A monitored.

Magnesium and aluminum containing antacids were reported to interfere with statin drug absorption. To avoid this interaction, take statin drugs two hours before or after any aluminum/magnesium containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

It should be noted that doctors often recommend supplementing with 100 mg of coenzyme Q10 per day for maintaining healthy levels. However, those on statin drugs may have a greater need for a higher dose. It further should be noted that the symptoms associated with the combination of grapefruit juice and statin drugs (muscle weakness and discomfort) are commonly reported as symptoms associated with CoQ10 depletions. Supplementation with coenzyme Q10 is strongly recommended.

The herbs Artichoke plant, Garlic and Plantain may decrease blood cholesterol levels, and therefore enhance the effects of Zocor. Consult with your pharmacist or physician before taking them.

All the best,
Lisa Nelson RD
Be Heart Healthy and Lose Weight